![Bicalutamide [Casodex] – (Androgen Receptor Inhibitor)](data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%200%200'%3E%3C/svg%3E)
Introduction
Bicalutamide, sold under the trade name Casodex, is an older-generation androgen receptor inhibitor used to treat prostate cancer. While still effective in certain settings, it is generally less potent than newer androgen receptor inhibitors like Enzalutamide, Apalutamide, and Darolutamide.
Purpose
- Used in combination with luteinizing hormone-releasing hormone (LHRH) agonists for the treatment of advanced prostate cancer.
- Helps reduce the effects of androgens on prostate cancer growth.
How It Works
Bicalutamide binds to androgen receptors in prostate cancer cells, blocking testosterone and other androgens from stimulating tumor growth.
Usage
- Taken as an oral tablet, typically once daily.
- Often combined with therapies to suppress androgen production, such as LHRH agonists or surgical castration.
Considerations
- Common side effects include hot flashes, gynecomastia (breast enlargement), and fatigue.
- Rare side effects include liver toxicity and cardiovascular issues; regular monitoring is recommended.
- Compared to newer androgen receptor inhibitors, Bicalutamide has a shorter duration of efficacy in advanced disease.
At Crossroads Urology
At Crossroads Urology, Bicalutamide may be used as part of a tailored prostate cancer treatment plan, particularly in settings where newer therapies are not indicated or available. Our providers evaluate all options to ensure optimal patient outcomes.
Conclusion
Bicalutamide [Casodex] is a foundational androgen receptor inhibitor that continues to play a role in prostate cancer management. Contact Crossroads Urology today to learn more about this treatment and other advanced options for prostate cancer care.
