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Enzalutamide [Xtandi] – (Androgen Receptor Inhibitor)

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Introduction

Enzalutamide, sold under the trade name Xtandi, is an oral androgen receptor inhibitor used to treat advanced prostate cancer. It works by blocking the effects of androgens (male hormones), which fuel the growth of prostate cancer cells.

Purpose

  • Treats metastatic castration-resistant prostate cancer (mCRPC).
  • Used in non-metastatic castration-resistant prostate cancer (nmCRPC) to delay disease progression.
  • Offers an effective treatment option for patients with advanced prostate cancer.

How It Works

Enzalutamide binds to androgen receptors in prostate cancer cells, blocking the ability of androgens like testosterone to stimulate tumor growth. It also interferes with androgen receptor activity within the cell nucleus, preventing cancer cell survival and proliferation.

Usage

  • Taken as an oral capsule, typically once daily, with or without food.
  • Regular monitoring of prostate-specific antigen (PSA) levels and other indicators is recommended to evaluate treatment efficacy.

Considerations

  • Common side effects include fatigue, hot flashes, nausea, and musculoskeletal pain.
  • Rare but serious side effects include seizures, falls, and cardiovascular events. Patients should be monitored closely for these risks.
  • Patients receiving Enzalutamide may require additional therapies to manage testosterone levels, such as luteinizing hormone-releasing hormone (LHRH) agonists.

At Crossroads Urology

At Crossroads Urology, Enzalutamide is a key component of advanced prostate cancer treatment. Our providers personalize care plans to optimize treatment effectiveness while minimizing side effects, ensuring the best possible outcomes for our patients.

Conclusion

Enzalutamide [Xtandi] provides a powerful and effective solution for managing advanced prostate cancer, improving survival rates and quality of life. Contact Crossroads Urology today to learn more about this treatment and how it can benefit you.